Anti-lipoperoxidation of Several Organic Polyphenol Acids in vitro

Abstract

Abstract: The natural polyphenol acids are reported to possess strong antioxidative activity.In this study,the effects of seven polyphenol acids including rosmarinic acid,coffeic acid,protocatechuic aldehyde,chlorogenic acid,ferulic acid,salvianic acid and 3-hydroxycinnamic acid,against lipid peroxidation in vitro were investigated. The thiobarbituric acid (TBA) assay was used to evaluate the spontaneous and H₂O₂ induced lipid peroxidation in rat liver homogenate.The results showed that all seven polyphenol acids possessed strong anti-lipid peroxidation activities.The order of their activities against H₂O₂ induced lipid peroxidation was rosmarinic acid > coffeic acid > protocatechuic aldehyde > chlorogenic acid > ferulic acid > salvianic acid > 3-hydroxycinnamic acid.The order of their activities against spontaneous lipid peroxidation was rosmarinic acid > protocatechuic aldehyde > chlorogenic acid > coffeic acid > ferulic acid > salvianic acid> 3-hydroxycinnamic acid.The anti-lipid peroxidation of seven kinds of organic acid existed significant differences for their different structure.

Key words: natural organic polyphenolic acids, lipid peroxidation, antioxidant capacity, structure-activity relationship

CLC Number:

R931.6

ZHANG Xiao-xiao, ZHANG Shuo, HUANG Xiao-yan, LI Gang, WANG Zhen-hua, MA Cheng-jun*. Anti-lipoperoxidation of Several Organic Polyphenol Acids in vitro[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2014, 26(3): 398-402.

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Anti-lipoperoxidation of Several Organic Polyphenol Acids in vitro

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