Screening of Endophytic Fungi from Medicinal Plant for Biotransformation of Sinomenine

Abstract

Abstract: In order to obtain sinomenine derivatives with anti-inflammatory activity,biotransformation of sinomenine was performed using endophytic fungi from medicinal plants.Among 84 endophytic fungi isolated from medicinal plants,five fungi possessed the capability of biotransforming sinomenine were screened out.The structures of metabolites were identified as(S)-disinomenine,(R)-disinomenine and sinomenine-N-oxide by TLC and NMR.Biotransformation is going to provide a new research direction for structural modification of sinomenine.

Key words: medicinal plant, endophytic fungi, biotransformation, sinomenine

CLC Number:

Q819

LIU Fa-gui, PAN Ye, DENG Ai-ping, LUO Dan, YANG Jin, GUO Zhi-yong, DENG Zhang-shuang*. Screening of Endophytic Fungi from Medicinal Plant for Biotransformation of Sinomenine[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2014, 26(2): 268-272.

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Screening of Endophytic Fungi from Medicinal Plant for Biotransformation of Sinomenine

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