Abstract: The objective of this study was to investigative the effect of Cynomorium songarium Rupr on the testosterone content,substance metabolism and anti-fatigue capacity in rats model.The rats were gavage with 0.75,1.5,4.5 g/(kg.d) doses of C.songarium. Weight-bearing swimming test was then carried out which was followed by the determination of serum testosterone and other biochemical indicators in 49 days.The results showed that exhaustive swimming time of C.songarium group was longer than that of motion control group (T group) (P<0.01).The content of serum testosterone of C.songarium group was higher than that of T group (P<0.01),but serum corticosterone was lower than that of the T group (P<0.05).The changes of content of serum testosterone were consistent with the changes of ratio of serum testosterone and corticosterone among different groups.The liver glycogen (P<0.05),muscle glycogen (P<0.01) and hemoglobin (P<0.05) in C.Songarium group were higher than these in T group,but the serum urea nitrogen were lower than the T group (P<0.05).The experimental results showed that the variances of testosterone and corticosterone content in serum caused by high-intensity exercise can be alleviated by C.songarium supplement to maintain the serum at normal physiological level.At the same time, C.songarium can promote protein synthesis,inhibit the decomposition of amino acids and proteins,increase the hemoglobin content and glycogen reserves.Hence,it showed the potential of anti-fatigue capability with multi-target,multi-channel features.

Key words: Cynomorium songarium Rupr, testosterone, anti-fatigue, luteinizing hormone, follicle-stimulating hormone