Abstract: The purpose of this study was to investigate the chronic toxicity of Alhagi pseudoalhagi (MB) Desv.extract in SD rats.120 health SD rats were randomly divided into low, middle and high dose groups.The rats were respectively treated with A.pseudoalhagi extract by oral administration,once a day for 3 months.The blank control rats were treated with carboxymethyl cellulose sodium.The hematology,biochemical indexes,electrolyte and histopathological were detected.No abnormal reactions showed during the administration of rats in each group.Some symptoms like body weight decline was detected in the high dose of A.pseudoalhagi extract treated rats compared with the controls;LYMPH,NEUT,RBC,HGB,PLT,BUN,K+, Na+ in the high dose groups were increased;ALB,CHO,GLU reduced significantly,at the normal range,there was no significant change in organ histopathology.The safety dose of A.pseudoalhagi extract for rats was not above 1.0 g/(kg·d) ［crude drug 22.7 g/ (kg·d)］.This study demonstrated A.pseudoalhagi extract has no significant side effects on rats.

Key words: Alhagi pseudoalhagi (MB) Desv.extract, rat, chronic toxicity