NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2014, Vol. 26 ›› Issue (11): 1835-1838.

• Article • Previous Articles     Next Articles

Study on Component and PTP1B Inhibition Activity of Fatty Acids of Anacyclus pyrethrum (L) DC

Gulnar KASIM1,3, MA Qing-ling2,3, Gulmira KAHAR1,3, Haji Akber AISA2,3*   

  1. 1 Postgraduate college of Xinjiang Medical University,Urumqi 830054,China; 2 The Key Laboratory of Plant Resources and Chemistry of Arid Zone,Xinjiang Technical Institute of Physics and Chemistry,Chinese Academy of Sciences; 3 State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization,Xinjiang Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Urumqi 830011,China
  • Online:2014-11-29 Published:2014-12-18

PDF (PC)

315

Abstract: Fats and oil components were extracted by Soxhlet extraction from Anacyclus pyrethrum (L) DC using three different organic solvent (n-hexane,diethyl ether,chloroform).The chemical constituents of fatty acids in different extracts were identified and semi-quantified by gas chromatography-mass spectrometry (GC-MS).The results indicated that 8 components,mainly including linoleic acid (36.341%),hexadecanoic acid (34.268%) and oleic acid (19.656%),were detected in the n-hexane extract;12 components,mainly including linoleic acid (34.102%),hexadecanoic acid (32.916%),oleic acid (20.000%) and α-linolenic acid (5.329%),were detected in the diethyl ether extract;5 components,mainly including linoleic acid (42.427%),hexadecanoic acid (40.952%) and oleic acid (11.250%),were detected in chloroform extract.In addition,the fatty acid extracts showed strong inhibiting effect on PTP1B,and their IC50 values were 5.27±0.40,4.71±0.08,7.01±1.98 μg/mL respectively.The results provided the basis for further study of Anacyclus pyrethrum (L) DC.

Key words: Anacyclus pyrethrum (L) DC, fatty acid, gas chromatography-mass spectrometry, PTP1B

CLC Number: