Chemical Components and Antitumor Activity of Essential Oil of Litsea cubeba Seed from Hainan

Abstract

Abstract: In this study,the essential oil from the seed of Hainan Litsea cubeba was extracted by supercritical carbon dioxide method.Fifty-two compounds were identified by GC-MS,which were 95.65% of the total essential oil.In addition,the antitumor activity of components of Hainan L.cubeba oil was investigated.The essential oil and the components from molecular distillation all showed antitumor activities.The essential oil from Hainan L.cubeba showed the best inhibitory effect against human gastric carcinoma cell with IC₅₀ of 6.29 μg/mL.The IC₅₀values of components D1,R1 D2 and R2 were 16.6,7.76,6.73 μg/mL and 5.97 μg/mL,respectively.

Key words: Litsea cubeba, volatile oil, antitumor activity

CLC Number:

O629.6

YU Chang-jiang1,2, SONG Xiao-ping1，2, ZHANG Xin2, HAN Chang-ri1,2*, ZHU Lin-hua1,2*. Chemical Components and Antitumor Activity of Essential Oil of Litsea cubeba Seed from Hainan[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2014, 26(11): 1849-1852.

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Chemical Components and Antitumor Activity of Essential Oil of Litsea cubeba Seed from Hainan

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