Inhibitory Effects of Alisma orientailis Extracts on α-Glucosidase of Mice

Abstract

Abstract: Slight modifications of microplate-based screening model were carried out with single factor and orthogonal experiments.The inhibitory effect of n-butanol fraction of Alisma orientailis (AOB) on mice intestinal α-glucosidase was assayed by this model.The results showed that AOB significantly inhibited mice intestinal α-glucosidase activity with a dose dependent manner with IC₅₀ value of 126 μg/mL in vitro and suppressed intestinal α-glucosidase activities in normal mice compared with control group after orally administered for 10 days.AOB has the potential to inhibit activities of mice α-glucosidase.

Key words: Alisma orientailis, n-butanol fraction, &alpha, -glucosidase, inhibition, screening model

CLC Number:

YI Xing1*, GUI Fei-fei1, YIN Hong-mei1, LU Yang-mei1, XIAO Xiao-nian2. Inhibitory Effects of Alisma orientailis Extracts on α-Glucosidase of Mice[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2013, 25(12): 1644-1648.

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Inhibitory Effects of Alisma orientailis Extracts on α-Glucosidase of Mice

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