Abstract: Twelve compounds including a tigliane diterpene ester,4α-deoxy-phorbol-13-acetate(1),a atisane diterpene, ent-(3β,13S)-dihydroxyatis-16-en-14-one(2),together with six triterpenoids,lanosterol(3),3-epi-glutinol(4),oleana-9(11),12-dien-3-one(5), β-amyrenone(6),olean-18-en-3-one(7),friedelin(8),and four other compounds,stigmast-4-en-3-one(9), β-sitosterol(10),kaempferol 3-O-α-L-rhamnoside(11)and scopoletin(12),were isolated from the 70% acetone extract of Euphorbia tirucalli. Their structures were elucidated by spectroscopic analysis,including 1D NMR,2D NMR and ESI-MS.Among them,compounds 1,2,5-7,9 and 12 were isolated from E.tirucalli for the first time.

Key words: Euphorbia tirucalli, diterpenoids, triterpenoids