NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2015, Vol. 27 ›› Issue (1): 35-40.doi: 10.16333/j.1001-6880.2015.01.007

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Study on Antioxidant and Antibacterial Activities of Carnosic Acid

XIA Tian-juan1, BI Liang-wu1,2*, ZHAO Zhen-dong1,2, XING Ya-li1, CHENG Xian1   

  1. 1 Institute of Chemical Industry of Forest Products,CAF;National Engineering Lab.for Biomass Chemical Utilization;Key and  Open Lab.on Forest Chemical Engineering,SFA;Key Lab.of Biomass Energy and Material,Jiangsu Province,Nanjing 210042,China; 2 Institute of New Technology of Forestry,CAF,Beijing 100091,China
  • Online:2015-01-31 Published:2015-02-12

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Abstract: The antioxidant and antibacterial activities of carnosic acid were studied by radical scavenging effect,reducing ability and tablet dilution methods.The results showed that,the antioxidant activity of carnosic acid was significantly higher than that of synthetic antioxidants PG,BHT,BHA,VE under the same concentration,while slightly lower than THBQ.At the same time,IC50s of scavenging DPPH and ABTS radical of carnosic acid were 2.53 μg/mL and 51.58 μg/mL,respectively.Antibacterial tests indicated that carnosic acid had broad-spectrum of antibacterial activity.Especially for Escherichia coli and Pseudomonas aeruginosa, the MICs of carnosic acid were 4 and <2 μg/mL,better than that of bromogeramine,sodium ampicillin and erythromycin.Moreover, for Klebsiella pneumonia, carnosic acid showed the same inhibitory effect with erythromycin,better than bromogeramine and sodium ampicillin.

Key words: carnosic acid, antioxidant activity, antibacterial activity

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