NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2015, Vol. 27 ›› Issue (1): 50-54. doi: 10.16333/j.1001-6880.2015.01.010

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Diketopiperazine Indole Alkaloids from a Marine-derived Fungus Eurotium amstelodami SCSIO 151

LUO Ming-he1,2, HUANG Hong-bo2, LU Lai-chun1*, JU Jian-hua2*   

  1. 1 Department of Pharmacy,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing 400042,China; 2 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology,RNAM Center for Marine Microbiology,Guangdong Key Laboratory of Marine Materia Medica,South China Sea Institute of Oceanology,Guangzhou 510301,China
  • Online:2015-01-31 Published:2015-02-12

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Abstract: Five echinulin-type compounds,variecolorin G (1),isoechinulin A (2),isoechinulin B (3),neoechinulin E (4),neoechinulin B (5) were isolated from a marinederived fungus SCSIO 151,which was identified as Eurotium amstelodami on the basis of its 18s rDNA sequence.The structures of compounds 1-5 were elucidated by a combination of 1D NMR,2D NMR and MS techniques.This paper was the first report of echinulin-type alkaloids produced by Eurotium amstelodami SCSIO 151 fermented in solid culture medium.

Key words: Eurotium amstelodami, echinulin-type alkaloids, marine-derived fungus, secondary metabolites

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