NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2015, Vol. 27 ›› Issue (1): 55-58.doi: 10.16333/j.1001-6880.2015.01.011

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Metabolites of Penicillium sp.F00120 from a Deep Sea Sediment Sample

TIAN Yong-qi1,2, LIN Xiu-ping1*, LIU Juan1, WANG Jun-feng1, YAN Bing1, JU Zhi-ran1, TAO Hua-ming3, LIU Yong-hong1*   

  1. 1 Key Laboratory of Tropical Marine Bio-resources and Ecology,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301,China;2 University of Chinese Academy of Sciences,Beijing 100049,China; 3 School of traditional Chinese medicine,Southern Medical University Guangzhou 510505，China
  • Online:2015-01-31 Published:2015-02-12

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Abstract: To study the chemical constituents of deep-sea fungus Penicillium sp.F00120,nine compounds were isolated from its EtOAc extract using silica gel,Sephadex LH-20,ODS and HPLC methods.Based on the spectroscopic analysis,their structures were identified as ergosterol (1),4-methyl-5,6-dihydro-2-pyranone (2), citreohybridonol (3),1-Linoleoylglycerol (4),5α,6α-Epoxy-(22E,24R)-ergosta-8(14),22-diene-3β,7β-diol (5),macrophorin (6),purpurogemutantin (7), 3-(2S,4S-dihydroxypentyl)-6,8-dihydroxyisocoumarin (8), 5-hydroxy-7-(2′-hydroxypropyl)-2-methyl-chromone (9).Compounds 2-4, 6-9 were isolated from Penicillium sp.F00120 for the first time.

Key words: deep-sea fungus, Penicillium sp.F00120, spectroscopic analysis, secondary metabolites

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