Study on the Whitening Activity and Pathway of Tricholoma matsutake TMSP-5Ⅱ

doi:10.16333/j.1001-6880.2015.01.027

Abstract

Abstract: The mechanism of whitening activity of Tricholoma matsutake TMSP-5II was studied in this paper.The evaluation of whitening activity was performed by Tyrosinase Inhibitory Activity (TIA) and melanin determination.The results showed that TMSP-5II can inhibit tyrosinase activity,and the inhibition rate was 56% with the concentration of 125 μg/mL.In addition,TMSP-5II can significantly inhibit the melanin production of B16 in a dose dependent way,and the inhibitory activity was better than that of arbutin. MITF, POMC and TYR were selected to perform the real-time quantitative PCR (RT-PCR) experiments in order to determine the possible targeting gene of TMP-5II and the results indicated that TMSP-5II played an important role in the reduction of expression levels of MITF, POMC and TYR, leading to a decreased melanin production.Therefore,TMSP-5II reduced the gene expression of the proteins that play an essential role in the production of melanin.

Key words: TMSP-5Ⅱ, whitening, melanin, genes

CLC Number:

Q949.95

WANG Qi1, WANG Ling2, HE Cong-fen1*, LIU Xiao-ying3, LIU Guang-rong3, LI Fu-heng2. Study on the Whitening Activity and Pathway of Tricholoma matsutake TMSP-5Ⅱ[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2015, 27(1): 134-138.

[1]	YI Liu-feng, TAO Si-yu, LI Meng, WANG Shao-li, LIU Zhen. Screening of key genes for Helicobacter pylori-associated gastritis and prediction [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2024, 36(7): 1200-1206.
[2]	HE Ting, WANG Yin-jie, ZHAN Ying-ying, MO Ting, YANG Li-juan, YANG Sen. Chemical composition analysis of Psoraleae Fructus alcohol extract by UPLC-Q-TOF-MS and its mechanisms of promoting melanogenesis [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2024, 36(6): 968-981.
[3]	DU Ruo-jun, SHI Zhao-hua, ZHAN Zhi-lai, HU Jun-jie, ZHENG Guo-hua. Optimization of the extraction process of total phenolic acid from Trollii Flos by response surface methodlogy and study on its whitening activity [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2023, 35(6): 915-924.
[4]	WANG Mei, LIU Yu-e, SU Da-peng, WANG Ying-xue, CHEN Hong-mei, DONG Xing-xing, HUANG Shen-rong, ZHANG Jin-qiang. Study on the effect of asperosaponin VI on neurogenesis and cognitive function in sleep-deprived mice [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2023, 35(5): 733-740.
[5]	WANG Jun, FU Jian-hong, WANG Yu-miao, RUAN Wen-wei, NIE Hui-lin, CUI Feng-zhen, . Identification of a Streptomyces setonii from Lop Nur and inhibition effects of its metabolites on tyrosinase activity and melanin synthesis [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2022, 34(9): 1548-1556.
[6]	XIA Yu, ZHANG Wen-zhen, HUANG Zhen, QIU Feng-mei, ZHONG Xiao-ming. Study on the re-extraction process and whitening activity of Curcuma wenyujin dregs [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2022, 34(3): 457-464.
[7]	RONG Wang, ZHU Zhan-lan, SONG Ya-yi. Screening of key genes and pathways of microvascular complications of diabetes mellitus and prediction of traditional Chinese medicine based on bioinformatics [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2022, 34(10): 1774-1783.
[8]	LI Bing, YANG Fei-yu, ZHANG Hong-xing, XIE Yuan-hong, LIU Hui, HAO Hong-wei. Optimization of fermentation conditions and antioxidant activity of exopolysaccharide produced by space-mutated Lactobacillus plantarum SS18-119 [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2021, 33(增刊2): 7-14.
[9]	GAO Xiao-meng, ZHAO Qi-yue, LIU Zi-qian, LIU Ling-jin, CHEN Ge-ge, HAO Juan, WANG Xiang-ting, XU Qing-you. Yiqi Huoxue Jiedu decoction inhibits lymphangiogenesis in contralateral kidney of UUO rats via VEGF pathway [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2021, 33(9): 1539-1547.
[10]	XIANG Jin-min, ZHAO Qiong-yu, YUAN Hang, PENG Zhen-hu, SONG Wei. Physicochemical properties and antioxidant activities of melanin from Chinese soft-shelled turtle (Pelodiscus sinensis) [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2021, 33(3): 453-461.
[11]	ZHANG Bing#, YAN Shi-ke#, BAO Chun-ling, LIU Ning, . Research progress of natural products targeting tumor angiogenesis [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2021, 33(3): 510-520.
[12]	ALIMIJIANG·Aobulitalifu, MA Jian-bao, YIZAITI·Waili, GULIBAHAER·Kawuli. Study on the mechanism of the total flavonoids from Lycium ruthenicum Murr. in the treatment of non-alcoholic fatty liver disease based on bioinformatics [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2021, 33(12): 2119-2135.
[13]	CHEN Liang1,2,3,LU Xue-ying4,5,HUANG Lie-jun2,3,JIAN Jun-you2,3,JIN Jun2,3,GU Wei2,3,YUAN Chun-mao2,3,HAO Xiao-jiang2,3*. Structural modification and inhibition of melanin content of curcumol [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2020, 32(2): 317-322.
[14]	GAO Ming-jie1,NIE Yan-fen1,ZHANG Hong-xing1,XIE Yuan-hong1,HAO Hong-wei2,LIU Hui1. Application of directed vat set yogurt starters by space Lactobacillus reuteri* [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2019, 31(增刊1): 136-142.
[15]	YANG Hui1,CHEN De-jing1,2*,XIA Dong-hui3,HAN Hao1,2,CHEN Hai-tao4. Extraction process and antioxidant activity of melanin from giant salamander skin [J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2019, 31(5): 888-895.

Study on the Whitening Activity and Pathway of Tricholoma matsutake TMSP-5Ⅱ

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments