NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2015, Vol. 27 ›› Issue (2): 226-231.doi: 10.16333/j.1001-6880.2015.02.006

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Optimization of Matrix Recipe of Bitongting Cataplasm by Box-Behnken Design

LI Zhi1, YU Jin-ying2,3, JIANG Yao3, YAN Qian-ru2, WANG Yun-hong3, HAN Li2, QIN Jian4, YANG Rong-ping2,3*   

  1. 1 Number One Orthopedic Hospital of Chengdu,Chengdu 610031,China; 2 Chengdu University of Traditional Chinese  Medicine(TCM),Chengdu 611137,China;3 Chongqing academy of Chinese Traditional Materia Medica,Chongqing 400065,China; 4 Chongqing Institute for Food and Drug Control,Chongqing 401121，China
  • Online:2015-02-15 Published:2015-02-15

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Abstract: Taking the early adhesion as evaluation indexes to optimize the prescription of Bitongting Cataplasm by Box-Behnken design.The optimal ratioof the prescription of Bitongting Cataplasm was as follows:PAAS:Kaolin:Aluminum glycinate :Citric acid =1.1:1.3:0.09:0.14.The optimal prescription showed that the average value of early adhesion was 3.30 cm,and the average relative error value was 2.30%.The optimal prescription had good early adhesive.It is indicated that Box-Behnken design was suitable for the optimization of Bitongting Cataplasm prescription.This study provided the foundation for the development of new prescription of Bitongting Cataplasm.

Key words: Box-Behnken design, cataplasm, prescription

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