Abstract: Recent studies of anti-adhesion mechanism of tetramethylpyrazine were reviewed to provide reference for clinical study and new drug development.It was found that the anti-adhesion mechanism of tetramethylpyrazine involved multi-targets and multi-links such as the inhibition of proliferation of collagen,over-expression of adhesion related factors,and reduction of the concentration of white blood cells and fibrin in plasma.In future,more clinical evidence was still required,and the basic research of tetramethylpyrazine should be focused on the biomaterial development.

Key words: tetramethylpyrazine, adhesion, pharmacological activity