Abstract: To investigate the antitumor activities of Alhagi sparsifolia shap.extract,cell proliferation was determined using methyl thiazolyl tetrazohum (MTT) assay.BGC823,Eca-109,HT-29 and HepG2 cancer cells were incubated in culture media containing Alhagi sparsifolia shap.extract.In order to determine the in vivo antitumor effect of A.sparsifolia extract,the CT26 colon cancer mice model was established.By comparing the relative tumor proliferation rate,growth curves,inhibition rate of different groups,the antitumor effect was evaluated.In the MTT assay, A.sparsifolia extract showed obvious antitumor effect on HepG2 and HT-29 cells.In the in vivo experiment, A.sparsifolia extract also exhibited significant antitumor effect.These results demonstrated that  A.sparsifolia extract can inhibit the tumor of CT26 in mice,the drug had obvious anticancer effects against HepG2 and HT-29.

Key words: Alhagi sparsifolia shap., antitumor, colon cancer, inhibition rate