Abstract: In recent years,drug-resistant bacteria has become a global problem.As the major source of antibiotics,microbes played an important role in the discovery of new antibiotics against drug-resistant bacteria,since many microbial natural products exhibited significant activity overcoming drug resistance.This report summarized microbial natural products against drug-resistant bacteria discovered mostly in last ten years,and generalized the methods of screening such microbial natural products,in order to providing a useful framework for the discovery of new antibiotics against drug-resistant bacteria.

Key words: natural bioactive products, drug resistance, drug discovery, antibiotic screening