Optimization of Extraction of Triterpenes from Kalimeris indica by Response Surface Methodology

doi:10.16333/j.1001-6880.2015.09.015

Abstract

Abstract: The objective of this study was to optimize the extraction of triterpenes from Kalimeris indica through response surface methodology.Based on single factor tests, Box-Behnken central composite design was applied to investigate the effects of ethanol concentration,solid/liquid ratio,ultrasonic duration,times of ultrasonic on the extraction yield of triterpenes and hence to optimize these extraction conditions.By means of regression analysis,the results showed that the optimized conditions were:ethanol concentration of 40%,solid/liquid ratio of 1:18 g/mL,extraction duration of 1 h and with 4 times of extraction.Under these conditions,the extraction yield of triterpenes reached 26.83 mg/g.The result indicated that the extraction system was efficient and reliable.

Key words: Kalimeris indica, extraction of triterpenes, extraction technology, response surface methodology

CLC Number:

R284.2

WANG Guo-kai, WANG Zheng, CAI Bai-xiang, GAO Wei-na, LIU Jin-song, WANG Gang*. Optimization of Extraction of Triterpenes from Kalimeris indica by Response Surface Methodology[J]. NATURAL PRODUCT RESEARCH AND DEVELOPMENT, 2015, 27(9): 1595-1600.

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Optimization of Extraction of Triterpenes from Kalimeris indica by Response Surface Methodology

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