NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2015, Vol. 27 ›› Issue (9): 1679-1686.doi: 10.16333/j.1001-6880.2015.09.030

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Review on Proteinaceous Cysteine Proteinase Inhibitors and Their Research Progress in Fish

LI Shu-hong*, JIANG Ran-ran, MA Lu-yang   

  1. Food Science College,Sichuan Agricultural University,Yaan 625014,China
  • Online:2015-09-25 Published:2015-09-28

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Abstract: This paper mainly overviewed cysteine proteinase inhibitors (CPIs),summarized the structural feature,inhibition mechanism as well as various activities and functions of the first group (Cystatins superfamily) of CPIs.In addition,a systematic review about the purification and characterization of CPIs from fish were presented.The potential activities and functions of fish CPIs in respect of development protection,immunoregulation,tumor inhibition and antibacterial action were summarized.Finally,the possible applications of fish CPIs were expected.

Key words: cysteine protease inhibitors, CPIs from fish, purification and characterization, activity and function, application prospect

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