Abstract: In this study,the anti-hyperglycemic,immunoregulation and antioxidant activities of raspberry pulp powder (RPP) on diabetic rats induced by streptozotocin (STZ) were investigated.The results revealed that RPP ameliorated the loss of body weight,lowered the blood glucose,and restored the damaged islet in diabetic rats.It was also found that RPP can effectively decrease the cluster of differentiation 4 (CD4),cluster of differentiation 8 (CD8),tumor necrosis factorα (TNF-α),interferon-γ (IFN-γ),interleukin-2 (IL-2),immunoglobulin G (IgG),immunoglobulin A (IgA) and immunoglobulin E (IgE) in the serum of the diabetic rats.Simultaneously,after RPP treatment,the activity of superoxide dismutase (SOD) and content of reduced glutathione (GSH) were significantly increased,while the content of malonaldehyde (MDA) was markedly decreased in pancreas tissue and serum of STZ-induced diabetic rats.Taken together,these results suggested that RPP functioned as an effective anti-diabetes component and it may protect the β-cells of the pancreatic islet through attenuating autoimmunity response and oxidative stress.

Key words: raspberry pulp powder, type I diabetes mellitus, anti-hyperglycemic, immunoregulation, antioxidant