NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2015, Vol. 27 ›› Issue (11): 1878-1883. doi: 10.16333/j.1001-6880.2015.11.008

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Chemical Constituents with Siderophores Activities from Trichoderma koningiopsis YIM PH30002

CHEN Jin-lian1,2, LIU Kai2, MIAO Cui-ping2, GUAN Hui-lin1, ZHAO Li-xing2*, SUN Shi-zhong1*   

  1. 1 College of Energy and Environmental Science,Yunnan Normal University,Kunming 650092,China; 2 Key Laboratory of Microbial Diversity in Southwest China of Ministry of Education and Laboratory for Conservation and Utilization of Bio-Resources,Yunnan Institute of Microbiology,Yunnan University,Kunming 650091,China
  • Online:2015-11-30 Published:2015-12-02

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Abstract: The semiquantitative analysis of siderophore produced by Trichoderma koningiopsis YIM PH30002 were detected by double-layer agar plate method.The results indicated the PDB medium was suitable for the strain YIM PH30002 to produce siderophore with maximum production.With further investigation,five polyketides were isolated from the ethyl acetate extract of the PDB fermentation broth of strain YIM PH30002 by various column chromatographical techniques.Their structures were elucidated as konginginin A (1),konginginin B (2),konginginin D (3),konginginin F (4),konginginin M (5) on the basis of spectroscopic analysis and literature data.Compounds 1-4 showed siderophore activities,among them compound 2 presented higher activity with MTC of 300 μg/mL in the iron (Fe III) acquisition tests.However,compounds 1-5 exhibited weak antimicrobial activities.

Key words: Trichoderma koningiopsis, siderophores, polyketides

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