Abstract: In order to study the foodborne material which have potential functions such as grape seeds and mulberries,comparing their different extracts on PC12 cells.The mulberries and grape seeds were extracted by different polar solvents (water,ethanol,ethyl acetate,n-hexane),measuring the effects of different extracts on PC12 cells.The results showed that the grape seeds extract influencing PC12 cells more than the mulberries.When the grape seeds water extract and ethanol extract tested in 50-500 mg/L,4h,the survival rate of PC12 cells had the most significant improvement.In consequence,grape seeds water extract and ethanol extract have the potential of cell protection,which can provide a theoretical basis for further experiment.

Key words: PC12 cells, mulberry extract, grape seed extract, coculture