Abstract: This article made preliminary study on the feasibility of the application of zeolite molecular sieves on enrichment and purification of alkaloid.The effects of different zeolite molecular sieves were examined based on indicators of adsorption rate and elution rate when lycorine in short-tube Lycoris aurea was taken as absorption object.Moreover,a comparison of effect was made with cationic resin to explore the optimal adsorption and elution conditions of zeolite molecular sieve.According to the result,ZSM-5 zeolite molecular sieve had better adsorption and elution effect,which were better than those of MCM-22 or 13X molecular sieve and D001 or HD-8 cationic resin.When pH value of upper sample liquid was 4,the adsorption effect of ZSM-5 zeolite molecular sieve was comparatively better;when 70% ethyl alcohol containing 2.0 mol/L ammonium hydroxide was taken as the eluent of lycorine,the elution effect was comparatively better.

Key words: zeolite molecular sieve, lycorine, absorption and purification