NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2016, Vol. 28 ›› Issue (3): 328-330.

• Article • Previous Articles     Next Articles

Secondary Metabolites from Deep-Sea-Derived Fungus Penicillium herquei FS83

LI Hao-hua,PAN Qin-ling,CHEN Yu-chan,LI Sai-ni,TAN Guo-hui, YE Wei,LIU Hong-xin,SUN Zhang-hua*,ZHANG Wei-min*   

  1. State Key Laboratory of Applied Microbiology Southern China,Guangdong Provincial Key  Laboratory of Microbial Culture Collection and Application,Guangdong Open Laboratory of Applied  Microbiology,Guangdong Institute of Microbiology,Guangzhou 510070,China
  • Online:2016-03-30 Published:2016-04-07

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Abstract: Five compounds were isolated from the extract of the deep-sea-derived fungus Penicillium herquei FS83 by utilizing various chromatographic methods such as silica gel,reverse silica gel,Sephadex LH-20,preparative TLC and HPLC.Their structures were identified as peniherin A (1),sclerodin (2),methyl (4-OH) phenylacetate (3),4-hydroxyacetophenone (4),(R)-mevalonolactone (5),respectively,by spectroscopic data.Compound 1 was identified as a new compound,and compound 2 was isolated from Penicillium for the first time.No cytotoxic and antibacterial activities were detected for compound 1.

Key words: Penicillium herquei, deep-sea-derived fungus;secondary metabolites;isocoumarin

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