NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2016, Vol. 28 ›› Issue (3): 395-399. doi: 10.16333/j.1001-6880.2016.3.013

• Article • Previous Articles     Next Articles

Antimutagenic Effect of Puerarin

ZOU Si-ying1,ZHANG Li-shi2*   

  1. 1 Sichuan Center for Disease Control and Prevention;2 West China School of Public Health,Sichuan University,Chengdu 610041,China
  • Online:2016-03-30 Published:2016-04-07

Abstract: In this study,the antimutagenic effect of puerarin were determined by TK gene mutation assay in L5178Y cells.Determination of mutant frequency of tk locus was performed according to the microcell method.The results showed that puerarin significantly inhibited the mutagenic effects of MMS and MMC in the pre-, post- and simultaneous treatments.Puerarin showed a good role for preventing TK gene mutation induced by MMS or MMC.

Key words: puerarin, mouse lymphoma assay, antimutagenicity

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