天然产物研究与开发 ›› 2019, Vol. 31 ›› Issue (增刊2): 194-199.doi: 10.16333/j.1001-6880.2019.S.028

所属专题: No.6

• 综述 • 上一篇    下一篇

岩藻多糖在制备、结构特征及心脑血管保护方面的研究进展

季宇彬1,尹嘉玉1,2,杨自勋1,2,侯蓬勃1,2,王进2,林萍2,宋晓童1,2,汲晨锋1,郭守东2*   

  1. 1哈尔滨商业大学药学院,药物工程技术研究中心,哈尔滨150076;2潍坊医学院,药学院,创新药物研发中心,脂代谢与动脉粥样硬化研究室,潍坊 261053
  • 出版日期:2019-12-28 发布日期:2019-12-30
  • 基金资助:

    国家自然科学基金(81770463,31300639);潍坊医学院科研启动基金(021824)

Preparation,structural characteristics of fucoidans and their cardio-cerebrovascular protective effects

JI Yu-bin1,YIN Jia-yu1,2,YANG Zi-xun1,2,HOU Peng-bo1,2,WANG Jin2,LIN Ping2,SONG Xiao-tong1,2,JI Chen-feng1,GUO Shou-dong2*   

  1. 1College of Pharmacy Engineering Research Center for Medicine,Harbin University of Commerce,Harbin 150076,China;2Institute of Lipid Metabolism and Atherosclerosis,Innovative Drug Research Centre,College of pharmacy,Weifang Medical University,Weifang 261061,China
  • Online:2019-12-28 Published:2019-12-30

摘要: 岩藻多糖是一种复杂的硫酸化多糖,富含L-岩藻糖和硫酸基团,可从褐藻及棘皮动物中获取。因其具有多种生物学活性而被广泛应用于医药和食品领域。本文阐述了岩藻多糖制备方法、主要的结构特征,并从抗血栓、抗凝血、抗炎、降血脂、免疫调节、抗氧化等方面阐述岩藻多糖在心脑血管保护方面的研究进展。

关键词: 岩藻多糖, 制备, 结构特征, 心脑血管保护, PCSK9

Abstract: Fucoidans were heterogeneous sulfated polysaccharides with abundant of fucose and sulfate groups,they can be extracted from brown algae and marine invertebrates. They were widely used in the fields of medicine and food due to their numerous biological functions. The purpose of this paper is to summarize the preparation and structural characteristics of fucoidans,and their potential protective effects in cardio-cerebrovascular diseases based on their biological functions such as antithrombosis,anticoagulation,antiinflammation,lipid-lowering,immunoregulation and antioxidation.

Key words: fucoidan, preparation, structural characteristic, biological function, PCSK9

中图分类号: 

R979.9