天然产物研究与开发 ›› 2022, Vol. 34 ›› Issue (增刊1): 99-103.doi: 10.16333/j.1001-6880.2022.S.015

• 开发研究 • 上一篇    下一篇

比较三种党参属中药对实验性便秘小鼠的通便及促消化作用

胡晓玉1,2,杨   园2,张兰胜1*,程永现2,3*   

  1. 1大理大学,大理 671000;2中国科学院昆明植物研究所 植物化学与西部植物资源持续利用国家重点实验室,昆明 650201;3深圳大学医学部药学院,深圳 518060
  • 出版日期:2022-06-01 发布日期:2022-05-19

Comparison of effects of three Codonopsis species on promotion of small intestinal digestion and purgation in mice with constipation

HU Xiao-yu1,2,YANG Yuan2,ZHANG Lan-sheng1*,CHENG Yong-xian2,3*    

  1. 1DaLi University,Dali 671000,China; 2 State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China;3School of Pharmaceutical Sciences,Health Science Center, Shenzhen University, Shenzhen 518060,China
  • Online:2022-06-01 Published:2022-05-19

摘要:

探讨候选的三种党参(臭党参、管钟党参和潞党参)对便秘小鼠的通便及促消化作用。采用复方地芬诺酯建立小鼠便秘和促消化模型,采用二次水提法获取党参水溶性物质,以临床换算剂量进行灌胃给药,记录首便时间、便粒数、便重、小肠炭墨推进率等指标来评价药效。结果表明,高、低剂量的臭党参能显著缩短首便时间、便粒数等指标,且具有时间依赖性;管钟党参只有在高剂量下具有促消化作用、在低剂量下具有通便效果,剂量要求严格;潞党参对各项指标的影响不大。因此,臭党参和管钟党参作为云南党参的代表,在通便及促消化作用上可能更具优势。

关键词: 臭党参, 潞党参, 管钟党参, 便秘, 通便作用, 促消化作用

Abstract:

To study the effects among three candidates,Codonopsis pilosula produced from Yunnan Province,C. pilosula produced from Shanxi Province,and C. blleyana, on promoting the ability of purgation and digestion of constipated mice.Performing intragastric administration with concentrations of diphonxylate to establish the model of constipation and dyspepsia,water-soluble compounds were extracted twice by water,then analyzed their effects of purgative capability by recording the indices of first stool time,number of stools and stools weight in model of constipation,and studied promotion of digestive ability by calculating the rate in small intestine in model of dyspepsia.The results showed that,the extract of C. pilosula produced from Yunnan Province demonstrated eminent performances on promoting the ability of purgation and digestion of constipated mice in multiple timing and dosage settings.The extract of C. blleyana also revealed the similar capability,however,in more strict dosage setting condition.After all,the extract of C. pilosula produced from Shanxi Province showed litter help in those experiments,indicating that it had not much effect in the study.Thus,this study showed that the excellent performance of C. pilosula produced from Yunnan Province and C. blleyana could lead to the foundation of developing health care products and provide new ideas in clinical application.

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中图分类号:  R96