Based on data mining,network pharmacology and molecular docking,this study explored the molecular mechanism of high frequency drug pair of Astragali Radix-Ginseng Radix et Rhizoma in the treatment of chronic obstructive pulmonary disease. The correlation model was established by using Apriori algorithm,and the Astragali Radix-Ginseng Radix et Rhizoma was found to be the high frequency drug pair. Cytoscape 3.7.2 software was used to construct the compound target network protein interaction network and perform topological analysis. Metascape database was used for GO enrichment analysis and KEGG pathway enrichment analysis,and the active component with higher degree value was screened for molecular docking. The results showed that there were 33 active components,206 related targets and 946 chronic obstructive pulmonary disease targets of Astragali Radix and Ginseng Radix et Rhizoma,and 64 targets were obtained. GO analysis included 1 629 biological processes,48 cell components,91 molecular functions and 247 KEGG enrichment results. The molecular docking results showed that ginsenoside Rh₂,hederagenin and kaempferol could bind AKT1,IL6,CXCL8,MAPK1 and TNF-α. In this study,it was concluded that Astragali Radix-Ginseng Radix et Rhizoma was the high-frequency drug pair for the treatment of chronic obstructive pulmonary disease of strengthening foundation and cultivating vitality in Xin’an,and the mechanism was preliminarily revealed.

"> strengthening foundation and cultivating vitality, Astragali Radix-Ginseng Radix et Rhizoma, chronic obstructive pulmonary disease, network pharmacology, Xin’an medicine