关键词: 低聚壳聚糖, 美拉德反应, 抑菌性

Abstract: The antibacterial activity of chitosan oligosaccharide (COS) derivatives produced by Maillard reaction between COS and glucose, maltose and xylose, respectively were studied. The antibacterial activity of COS and its derivatives on Escherichia coli and Staphylococcus aureus were determined. The results indicated that the COS and its derivatives exhibited higher antibacterial activity on S,aureus than that on E.coli, and the antibacterial activity increased with the increasing of concentrations. The antibacterial activity of most of the derivatives was better than that of COS, and the antibacterial activity of CG 1:1 8h (the molar ratio of amino and carbonyl was 1:1, which reaction time is 8 hours) was the best, while CM 1:3 8h (the molar ratio of amino and carbonyl was 1:3, which reaction time is 8 hours) showed the weakest inhibitory action to the two strains. The results showed that the antibacterial activity of COS derivatives may be related to the kind of reducing sugar, the ratio of COS and reducing sugar, as well as the time of reaction.