NATURAL PRODUCT RESEARCH AND DEVELOPMENT ›› 2022, Vol. 34 ›› Issue (增刊1): 99-103. doi: 10.16333/j.1001-6880.2022.S.015

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Comparison of effects of three Codonopsis species on promotion of small intestinal digestion and purgation in mice with constipation

HU Xiao-yu1,2,YANG Yuan2,ZHANG Lan-sheng1*,CHENG Yong-xian2,3*    

  1. 1DaLi University,Dali 671000,China; 2 State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China;3School of Pharmaceutical Sciences,Health Science Center, Shenzhen University, Shenzhen 518060,China
  • Online:2022-06-01 Published:2022-05-19

Abstract:

To study the effects among three candidates,Codonopsis pilosula produced from Yunnan Province,C. pilosula produced from Shanxi Province,and C. blleyana, on promoting the ability of purgation and digestion of constipated mice.Performing intragastric administration with concentrations of diphonxylate to establish the model of constipation and dyspepsia,water-soluble compounds were extracted twice by water,then analyzed their effects of purgative capability by recording the indices of first stool time,number of stools and stools weight in model of constipation,and studied promotion of digestive ability by calculating the rate in small intestine in model of dyspepsia.The results showed that,the extract of C. pilosula produced from Yunnan Province demonstrated eminent performances on promoting the ability of purgation and digestion of constipated mice in multiple timing and dosage settings.The extract of C. blleyana also revealed the similar capability,however,in more strict dosage setting condition.After all,the extract of C. pilosula produced from Shanxi Province showed litter help in those experiments,indicating that it had not much effect in the study.Thus,this study showed that the excellent performance of C. pilosula produced from Yunnan Province and C. blleyana could lead to the foundation of developing health care products and provide new ideas in clinical application.

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